Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Epistaxis

Spontaneous, recurrent epistaxis

Gastrointestinal hemorrhage

Hematemesis

Hematochezia

Melena

Cerebral hemorrhage

Subarachnoid hemorrhage

Pulmonary hemorrhage

Spontaneous hematomas

Anemia

Polycythemia

Venous thrombosis

Hematological neoplasm

Hepatosplenomegaly

Disease(s) Associated with SMAD4

hereditary hemorrhagic telangiectasia

juvenile polyposis syndrome

juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome

Lynch syndrome

pancreatic cancer

Mouse Phenotypes		abnormal embryonic hematopoiesis	small thymus	abnormal thymus physiology	decreased osteoclast cell number
Availability	Mouse Genotype	abnormal embryonic hematopoiesis	small thymus	abnormal thymus physiology	decreased osteoclast cell number
	Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Kdr^tm1(cre)Sato/Kdr⁺ (conditional)
	Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Tg(Foxn1-cre)8Ghr/0 (conditional)
	Smad4^tm2.1Cxd/Smad4^tm2.1Cxd Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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